Home / Health & Beauty / The same researcher who 20 years ago made the discovery that linked abnormalities in egg chromosomes in mice to BPA, has just published a new study that found reproductive defects in mice housed in plastic cages made with BPA alternatives, suggesting that BPA-free products may not be safe. : Health

The same researcher who 20 years ago made the discovery that linked abnormalities in egg chromosomes in mice to BPA, has just published a new study that found reproductive defects in mice housed in plastic cages made with BPA alternatives, suggesting that BPA-free products may not be safe. : Health

The title of the post is a copy and paste from the second and third paragraphs of the linked academic press release here :

The discovery is a déjà vu moment for Patricia Hunt, who 20 years ago linked abnormalities in egg chromosomes to BPA released by a harsh detergent used on her lab’s mouse cages. This time, she saw reproductive defects in control animals housed in plastic cages made with BPA alternatives.

“There’s growing evidence that many of these common replacements are not safe,” said Hunt, a professor in WSU’s School of Molecular Biosciences and lead author of a study in the latest Current Biology. “

Journal Reference:

Tegan S. Horan, Hannah Pulcastro, Crystal Lawson, Roy Gerona, Spencer Martin, Mary C. Gieske, Caroline V. Sartain, Patricia A. Hunt.

Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.

Current Biology, 2018;

DOI: 10.1016/j.cub.2018.06.070

Link: https://www.cell.com/current-biology/fulltext/S0960-9822(18)30861-3

Highlights

Replacement bisphenols are structural BPA variants with similar biological effects Common bisphenols are germline toxicants that induce meiotic effects in both sexes Genotoxic bisphenol exposure effects may persist for several generations in males Environmental contaminants can undermine science by affecting data and conclusions

Summary

20 years ago, accidental bisphenol A (BPA) exposure caused a sudden increase in chromosomally abnormal eggs from our control mice [1]. Subsequent rodent studies demonstrated developmental effects of exposure with repercussions on adult health and fertility (e.g., [2, 3, 4, 5, 6, 7, 8, 9]; reviewed in [10, 11, 12, 13, 14, 15, 16, 17]). Studies in monkeys, humans, fish, and worms suggest BPA effects extend across species (e.g., [18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30]; reviewed in [31, 32, 33]). Widespread use has resulted in ubiquitous environmental contamination and human BPA exposure. Consumer concern resulted in “BPA-free” products produced using structurally similar bisphenols that are now detectable environmental and human contaminants (e.g., [34, 35, 36, 37, 38, 39, 40, 41]). We report here studies initiated by meiotic changes mirroring our previous BPA experience and implicating exposure to BPS (a common BPA replacement) from damaged polysulfone cages. Like with BPA [1, 2, 5], our data show that exposure to common replacement bisphenols induces germline effects in both sexes that may affect multiple generations. These findings add to growing evidence of the biological risks posed by this class of chemicals. Rapid production of structural variants of BPA and other EDCs circumvents efforts to eliminate dangerous chemicals, exacerbates the regulatory burden of safety assessment, and increases environmental contamination. Our experience suggests that these environmental contaminants pose a risk not only to reproductive health but also to the integrity of the research environment. EDCs, like endogenous hormones, can affect diverse processes. The sensitivity of the germline allows us to detect effects that, although not immediately apparent in other systems, may induce variability that undermines experimental reproducibility and impedes scientific advancement.


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